Neurohormonal Activation, Angiogenesis, and Heart Failure

The aim of the studies was to investigate: 1) whether changes in microvasculature, angiogenesis and angiogenesis factors occur in heart failure, and affect its outcome and 2) whether neurohormonal correlates can be identified that modulate these factors,and 3) whether correcrion of the microvascular abnormalities with specific neurohormonal inhibitors is possible.

It was shown that changes in microvasculature, angiogenesis and angiogenesis factors occur in heart failure, although it is not established yet whether changes in microvasculature, angiogenesis and angiogenesis factors affect the outcome of heart failure. The second aim yielded data on the impact of neurohormonal parameters, and signaling proteins that confer neurohormonal activation. We established that blockade of the AT receptor, beta-receptor and ERK may be involved in microvascular abnormalities.